Research Article

Protective Effects of Tribulus Terrestris L Extract Against Kidney Injury Induced By Sorafinib in Rats

Abstract

Medicinal plants or their secondary metabolites have shown different biological effects with a wide range of pharmacological properties, one of these medicinal plants is Tribulus terrestris (Tt). The purpose of this research was to evaluate the possible protective effects of Tribulus terrestris fruit aqueous extract against nephrotoxic effect of Sorafinib (Sor), Sorafinib an oral anti-cancer drug approved for the treatment of advanced renal cell carcinoma (RCC). Albino Wistar rats were divided into normal control, Sorafinib alone treated group, Interaction groups and Tribulus terrestris alone treated group. The extract was administered at a dose of 300 mg/kg body weight, 600 mg/kg body weight for 4 weeks orally by gavage and Sorafinib was administered at a dose of 60 mg/kg body weight for three weeks orally by gavage. The findings showed that administration of Sorafinib caused a significant increase in Urea, Uric acid and Creatinin levels in comparison to negative control, Additionally significant decreases in this levels in Interaction groups compared in comparison with the positive group. The present study demonstrated the therapeutic effect of aqueous extract of Tribulus terrestris fruit on oxidative stress-induced nephrotoxicity of sorafenib in experimental rats.