Journal of Biomedicine and Biosensors


Molecular Diagnostic Study of Causes of Anaphylaxy During One Year of Follow-Up

  • By Alicia Armentia Medina, Angel San Miguel Rodríguez, Blanca Martín-Armentia, Sara Martín-Armentia, Angel San Miguel Hernández - 12 Dec 2022
  • Journal of Biomedicine and Biosensors, Volume: 1, Issue: 1, Pages: 15 - 32
  • Received: 15 June 2021; Accepted: 28 July 2021; First Online: 10 August 2021


Anaphylaxis is a severe and rapidly onset hypersensitivity reaction. It is triggered by the patient's contact, previously sensitized, with different external agents. The aim of the study has been to discover the causes of individualized anaphylaxis in patients to help prevent future anaphylactic reactions. Among the most important allergens as a cause of anaphylaxis in the area of our hospital, the pollens stood out: Pol1, Cynd1 and Alt1; among foods: Prup3, Cora8 and Walnut; and among the animals the cat turned out to be the animal that triggers the most anaphylaxis in our environment. Knowing which epitopes are causing the patient's allergy through faster and higher-throughput techniques such as microarrays makes more targeted therapy possible. Therefore, the molecular analysis by microarrays was more useful in the diagnosis and in the possible future treatment of the patients because it will allow a dietary elimination and a more targeted immunotherapy. In addition to being more efficient compared to other allergenic studies.

Keywords: Anaphylaxis, prevalence, allergy, microarray, prick, IgE.