Article

Quantitative Screening of Corchoriusolitorius and the Effects of Methanol Extract of Corchoriusolitorius on Heamatological Indices and Electrolytes of Wistarrats

Abstract

This study shows the quantitative screening of Corchoriusolitoriusand the effects of methanolic extract of Corchoriusolitorius leaves on hematological indices and electrolytes of wistar rats. Methods: A total of thirty adult wistar rats weighing 85-110g were randomly divided into five groups, with 6 rats each respectively in each of the group. Normal control was administered with distilled water Group A to D was administered 100mg/kg, 150mg/kg, 250mg/kg, and 300mg/kg respectively of the plant extract. The extraction and all biochemical analysis were carried out using standard laboratory techniques. This experiment lasted for 14 days, and the hematological indices of wistar rats administered with Corchoriusolitorius leaves extract were investigated. Results: It was evident that administration of rats with Corchoriusolitorius leaves extract caused significant changes at (p<0.05) in the white blood cell count (WBC) of the administered groups compared to the normal control group due to the extract. However, the administered group showed no significant increase in packed cell volume (PCV) compared to the control, this is because of the non toxic nature of the plant. The chloride concentration in groups A, B, C, and E administered 100, 150, 250and 300 mg/kg b.w. of the extract, respectively, was not significant at (p<0.05) compared to the normal control group. There was a non-significant difference at (p<0.05) in potassium concentration when compared to the control group. The concentration of sodium in groups A, B, C, and D administered 100, 150, 250, and 300 mg/kg b.w. of the extract, respectively, was significant at (p<0.05) compared with the normal group. Also this research investigated the phytochemical constituent of the extract and the result of the phytochemical screening showed that Corchoriusolitorius leaves contained appreciable amount of metabolite such as tannins, terpeniods, phenols and quinones are present in high quantity while steroid was available in low quantity. Conclusion: The study recommended that Corchoriusolitorius leaves be given to pregnant women with low blood count, and anemic patients as it helps in increasing blood volume.

Keywords: Medicinal plant, haematology, electrolytes, phytochemicals, treatment.