Review Article

Emergence of New Variants of Cannabis Use: A Systematic Review

Abstract

This research reviews evidence on new variants of cannabis use and rapid expansion and exposure of these new modes. New variants identified include edibles, delta-8 THC products, vaping, concentrates or dabbing, synthetic cannabinoids, new-edible formulations and beverages. Data were collected from already existing journals, reviews, documents that provided proper information on the research topic. Results showed a rapid increase in the use of high-potency concentrates and new inhalation techniques, and its association with behavioural changes. Delta-8 THC was discovered to be increasingly available leading to rising exposures and regulatory concerns, a persistent threat from synthetic cannabinoids and the diversification of non-inhaled cannabis products in form of beverages and nanoemulsions. Severe harm caused include high-toxicity episodes from synthetic cannabis, poison control surges with exposure to delta-8, and outbreak of lung damage similar to EVALI.